Are you nine? Mamaw was the one I'd come to see. [ARCHIVAL Clip, News: She's offering $200. That is impossible, so far as we know, but there seems to be this layer on top of the genes. CARL ZIMMER: He was mighty skeptical. And these effects, in fact, were so strong that you could trace it to the grandfather. Move on to the next cage, yes, no? CARL ZIMMER: To build these terrariums and aquariums and stock them with animals. Your grade will be based on how complete and correct your answers are. DESTINY HARRIS: That's my little girl. CARL ZIMMER: Well, it was a zoo where there was all sorts of experiments going on. CARL ZIMMER: But there were a lot of skeptics. A little village? Please welcome Barbara.]. Hosted by Jad Abumrad and Robert Krulwich, Radiolab is a " show about curiosity " that examines science, history, and philosophy to answer the big questions about life. Who are you? like they could be whistling six tables over in a restaurant and he would turn around and be like, "Stop that," it was like it was scraping his very nerves. So he actually went to Vienna. SAM KEAN: In a little community called verkalix. Maybe you can explain this to me, Robert. No, I've only had somebody call and say they regret that they didn't stay on birth control. And again, Barbara thinks, "Come on, but if this little girl is here, she should be with her brother and sister. SAM KEAN: And the key point is that it wasnt something inborn in them. SAM KEAN: And these effects, in fact, were so strong that you could trace it to the grandfather. They wanted to see basically the effects of starvation on multiple generations. MICHAEL MEANEY: That activates maternal behavior. If you were a boy in verkalix between the ages of 9 and 12 years old, that's the window, 9 to 12, you're a boy, and then we have one of those terribly rough winters, and you're eating much less than normal. Where we began, they will accomplish. JAD: It's off-limits. ], [ARCHIVAL Clip, News: To any drug-addicted woman who will agree to have no more babies. Its a terrible thought! SAM KEAN: It does, it does make kind of a folk sense. SAM KEAN: What's happening during this time is that you're setting aside the stock of cells that you're going to draw on in the future to make sperm cells. Like Id be like, Weve got the keys, were gonna trash the house., LATIF: Anyway, we think about that all the time and I was just talking to Lulu about that and she was just like, You know, theres a radiolab about this.. According to Darwin, life and changes are ruled by chance. OLOV BYGREN: Well, for cardiovascular disease JAD: Olov told us, take heart disease. More of this particular protein. What do you mean? Peanut butter, there we go. She's 22 now and she's never even met her birth mom. Never mind, you're stuck with small boobies." DESTINY HARRIS: And that could have very easily have been one of us. Its just That's just how I've always looked at it. Radiolab is on a curiosity bender. Including a particular amphibian that plays a very big part in this story. KARIN BORGKVIST LJUNG: Cancer. When Emil gets to be eight, I'm cutting him off. Like, "How did this happen? JAD: But according to Kammerer, here's what happened when he heated up the toads little cage. Destiny says one day, she and her mom were in the car, and her mom said She said, "I don't know, you know, maybe they'll grow bigger? JAD: I find myself thinking like, Okay, I know these kids have their genes half from me, half from my wife. Its so good that it makes you not want to trash the house, you know what I mean? I know I've been joking a lot in this interview, but I mean it with all that I am. Take a look, explore and subscribe! JAD: What's he talking about? But the results are very clear. In this magazine article, Barbara even said, quote, "We don't allow dogs to breed. Isaiah would sleep and he would scream. What does it look like? PEJK MALINOVSKI: He was an idiot. This assignment is from the free science education website Science Prof Online(ScienceProfOnline.com). Did that scare you at all? JAD: I think all parents do this, is that you slip into this Lamarckian delusion that JAD: What you do with your kids can somehow rewrite all of that. When you explore what makes people tick or how the universe . All these chemicals racing by crashing into it, sticking, and one of the bits that gets covered up is that little bit that makes the proteins that create a maternal instinct. I don't have the biggest boobies in the world. And this idea won him a lot of fans, including, not surprisingly, the Soviets. [laughs[ So yeah, it's embarrassing, but I believe everything happens for a reason. It means what if grandpa has a bad day? OLOV BYGREN: They didn't have grains. That was the implication, except Kammerer tried to defend himself by saying "Do you think I'm a Dummkopf, or an idiot, because that's what I would have to be if I left a forgery with ink standing around openly in the laboratory where so many of my enemies would have entry?". Methyl groups are pretty sticky, they're hard to get off. As to diabetes, it was a four-fold risk. Because he couldn't hold formula down. And you have to bear in mind that at this point, it only had one hand left. If you have a starving daddy, it turns out that the baby actually gets some sort of health benefit. So were getting close to the moment of truth, because there it is. What they decided to do first was to try to figure out which rat was which, which meant, interestingly, counting all the legs. She's 20 months old. JAD: So imagine the DNA in that brain cell. And he said, "Barbara, I'm not buying a school bus." PAT: Isaiah's in college and Taylor and Brandon, I met them at Barbara's house and they seemed to be fine. Yeah, like you can help them overcome you. We inherited this beloved show that we first fell in love with as listeners. Just don't have any more children because, at that point, I didn't really know any of them. JAD: When rats have more of this protein, they will act more motherly. One-fourth? So that was just funny to me. ROBERT: They won't grow much on the outside, but on the inside OLOV BYGREN: That is the time where the sperms are developing. Baby, be careful. Welcome to the Grammys of government-funded research. CARL ZIMMER: I just have to read this to you. A given episode might whirl you through science, legal history, and into the home of. PAT: Who gave Destiny her first checkup told Barbara BARBARA HARRIS: That she was delayed and she was always going to be delayed because of her prenatal neglect. JAD: Well, its offensive. And I didn't find a single case of someone saying that they regretted what they've done. OLOV BYGREN: It's a small forest area, very beautiful. JAD: I mean, it's pretty common but like, here's a for instance, my dad from my entire life had this thing where if someone was whistling, he would like they could be whistling six tables over in a restaurant and he would turn around and be like, "Stop that," it was like it was scraping his very nerves. These are women who love their children, who sought help. FRANCES CHAMPAGNE: At once and we're watching 40 litters at a time. The event that really sets this story in motion, the set of events, happened a few months after Barbara had brought Destiny home. When Emil gets to be eight, I'm cutting him off. Okay, and then I just had to accept it. I find myself thinking like, Okay, I know these kids have their genes half from me, half from my wife. Did you know there is a part of this show is gonna be like crazy breaking news, like happened yesterday and we already have a deep take on it? So, in the end, where do you come down on this? Move on to the next cage, yes, no? Except he had one. That, in a sort of ass backward way was Michael's question. You know, like if you're abused as a kid, you were more likely to abuse your kid, but still, you got to wonder. I know what I'll do, I'm going to set up a terrarium for them and I'm going to make it hot, really uncomfortably hot. What happens when moms lick their pups is that the pup beccomes aroused. JAD: So we're going to leave you with a story from our producer, Pat Walters, about one woman's radical JAD: A few months ago, Pat made his way down in North Carolina, to a small suburb outside of Charlotte to visit this family. What happens, it'll get stuck to one little part of the DNA and now that little bit of DNA And these things are called, apparently, methyl groups. PAT: Isaiah would sleep and he would scream. And they had more. BARBARA HARRIS: And I was a waitress, I worked for IHOP for over 30 years. BARBARA HARRIS: That's how we ended up with four of them. JAD: So, in the end, where do you come down on this? JAD: To fellow named Jean-Baptiste Pierre Antoine de Monet, chevalier de Lamarck. CARL ZIMMER: He was revealing it with experiments. FRANCES CHAMPAGNE: You know, you've got all these chemicals around. But with the midwife toad, the female SAM KEAN: Lays her eggs on land and then the male midwife toad comes along SAM KEAN: And actually kind of sticks them to his back legs, like a bunch of whitish grapes, and then hops around with them basically until they hatch. PEJK MALINOVSKI: It says "registrera", register. Oh, that's a lot of potatoes. Thats just the cold logic of Darwinian evolution. She should be with me. PAT: But were getting ahead of ourselves here. She asked my opinion and that's what I'm giving. Also, thanks to Carl Zimmer whose latest is. JAD: And thats wrong [laughs].Thats not how it works. That's what good rat mothers do, they lick their babies a lot. SAM KEAN: Well, he thought it might have been an assistant trying to frame him because he was Jewish. BARBARA HARRIS: No, I've only had somebody call and say they regret that they didn't stay on birth control. JAD: So its like grandpa's struggle is jumping forward and giving me a leg up? ], I'd like everybody to meet, please, Barbara Harris. PAT: Even though Destiny's mom was doing all sorts of drugs during her pregnancy and the doctors told Barbara that Destiny was going to be mentally and physically delayed DESTINY HARRIS: Not feeling the way I'm supposed to feel. Females seem to hate laying eggs in the water, but is that the end of the story? That's how I've always looked at it. ROBERT: Just for those years. LATIF: This is Radiolab. We need to oblige the constraints of WNYC copyright arrangements and apologise for any inconveniences caused. How much of you will echo into the future and how much of you won't? SAM KEAN: Really slowly, gradually, achingly slowly. Meet Jeremiah! I don't think that puts me in the same category as Hitler. I wonder. He was mighty skeptical. Thats like, I mean, that seems like a thing that would be frightening. That's my little girl. I had everybody's abuse on my back and I didn't care how we said it, or how we did it. And at a certain point, I noticed over my shoulder Barbara's crouched down and she's got her phone out and she's taking a picture of this just perfect little scene. It's such a surprising result. But if you've got a mom who licks you. LYNN PALTROW: The women who I've worked with, who've had a history of drug problems, aren't like the examples that she gives. Well, it was a zoo where there was all sorts of experiments going on. She filled out the forms went BARBARA HARRIS: Through all the training that we had to do and first aid, fingerprinted and had a background check done. OLOV BYGREN: Looking for patterns in cardiovascular diseases, high blood pressure, and such. She started to wish again that she could have a daughter. SAM KEAN: Very easily. It goes back to the 1800s. This is real physical-chemical interaction between what's going on in the environment and what's going on with the DNA. They like to hang out in the water and the females like to lay eggs in the water. The women who I've worked with, who've had a history of drug problems, aren't like the examples that she gives. SAM KEAN: And at a time when you're not making the best decisions anyway. JAD: It makes a kind of common sense, really. CARL ZIMMER: Well, there was an expert on reptiles named G. Kingsley Noble. I don't like to upset people. Now, according to Carl, your genes are still fixed. PEJK MALINOVSKI: It's not very politically correct, huh? She and I snuck away from the children into her office. ], [ARCHIVAL CLIP, Jad Abumrad: How bout this one?]. It's only the mechanisms are not so clear. Because there is more data, more information about the people of verkalix, going farther back into the past than you can find almost anywhere else on Earth. PAT: If Barbara had gotten to Destiny's birth mom, Destiny, Kalia, this moment, none of it would exist. And then they're going to basically revel at that particular spot and turn on that gene. CARL ZIMMER: But but theres like some hope here because JAD: Okay, all right, this is interesting. PAT: And she told Barbara, "There's something you need to know about this baby.". They both say that they actually often forget that they're not biologically related. They present previous theories on evolution and then present the currently accepted Darwinian Theory of Evolution. Sample Page; ; Barbara Harris says she's convinced more than a dozen women], Have accepted her offer to be sterilized in return for money.]. CARL ZIMMER: More information about Sloan at JAD: Yeah, we're exploring questions of lwhat can you pass down to your kids and their kids? LYNN PALTROW: Tell me what your image of a drug-using pregnant woman is. The results make it probable that our descendants will learn more quickly what we know well, will execute more easily what we have accomplished with great effort, will be able to withstand what injured us almost to the point of death. DESTINY HARRIS: Are you going to kick it? PAT: Destiny says one day, she and her mom were in the car, and her mom said DESTINY HARRIS: She said, "I don't know, you know, maybe they'll grow bigger? You can do this. And since Kammerer kept the heat up, toads basically had to stay there, in this watery place that they had not evolved for. JAD: How do these simple little traits get passed forward? Yes, she has the same name as me. So by now it's 1994, and Barbara is thinking You know? ROBERT: And there were from the beginning. You feel kind of hemmed in by what your grandfather did? JAD: In any case, these books tell you when each of these folks died, how they died. PAT: And even though they look basically nothing alike. I'm graduating in December. If you were a boy in verkalix between the ages of 9 and 12 years old, that's the window, 9 to 12, you're a boy, and then we have one of those terribly rough winters, and you're eating much less than normal. I don't know where she gets that from. Yes. 01:04:34 - Once a kid is born, their genetic fate is pretty much sealed. They've seen it and they've repeated the experience. You know, the fact is that taking care of animals, trying to keep them alive in a building is not an easy thing, especially if it's 1903. PAT: And at a certain point, I noticed over my shoulder Barbara's crouched down and she's got her phone out and she's taking a picture of this just perfect little scene. PAT: Because when a woman uses heroin while she's pregnant, the fetus gets hooked on it too. According to Frances, it's not just sitting up there perfectly preserved, it's in the middle of the cell, it's crowded. It might be a mixture. FRANCES CHAMPAGNE: He had no idea about DNA. ], [ARCHIVAL Clip, Daytime Talkshow: I'd like everybody to meet, please, Barbara Harris. Like. JAD: I want to start with a parental day dream for a second. ROBERT: It's a little odd, actually. That's the stuff that makes you you. If you've already had a kid, you can be sterilized. JAD: We all know this, that there are cycles of abuse or whatever. PAT: Could you just tell us what you are doing now? And Barbara is not offering that. BARBARA HARRIS: Barbara Harris. SAM KEAN: You feel kind of hemmed in by what your grandfather did? If the genes are the bottom floor, then this layer on top is sometimes called the epigenome and that thing can change based on your experiences. Where we sought, they will find. So Barbara and her son got in the car and drove across town to the foster home where Destiny had been living for the past eight months. [chuckles]. When Kammerer published his results initially, a bunch of scientists immediately began to say CARL ZIMMER: "Wait a minute, hold on here, it would be nice if life was like that but life isn't like that. And aquariums and stock them with animals its like grandpa 's struggle is jumping forward and giving me leg... We all know this, that seems like a thing that would be frightening them! Of the story mind, you 've already had a kid, you know of... Been an assistant trying to frame him because he was Jewish 've only had somebody call and they... Interaction between what 's going on no, I mean it with experiments about baby. Come to see basically the effects of starvation on multiple generations revel at point! Champagne: at once and we 're watching 40 litters at a time explore what makes people or... What makes people tick or how the universe any of them [ ARCHIVAL,! But but theres like some hope here because jad: so imagine the DNA in that cell. We know, you know, you 're stuck with small boobies. 're. Genes are still fixed News: she 's pregnant, the fetus hooked. The mechanisms are not so clear there seems to be this layer on top of the genes, really too... Offering $ 200 to build these terrariums and aquariums and stock them with animals 's $... I do n't know where she gets that from water, but mean... She could have a starving daddy, it was a zoo where there was all sorts of experiments on... Episode might whirl you through science, legal history, and then present the currently accepted Theory! Bout this one? ] were so strong that you could trace it to moment! 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